Reactome | Toll Like Receptor 4 (TLR4) Cascade

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Toll Like Receptor 4 (TLR4) Cascade Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222785
displayName	Toll Like Receptor 4 (TLR4) Cascade
eventOf	[Pathway:R-RNO-168898] Toll-like Receptor Cascades - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259012] toll-like receptor 4 signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-166015] Association of LBP with LPS - Rattus norvegicus [Pathway:R-RNO-166020] Transfer of LPS from LBP carrier to CD14 - Rattus norvegicus [Reaction:R-RNO-166041] Transfer of LPS onto TLR4 - Rattus norvegicus [Reaction:R-RNO-2201293] Endocytosis of TLR4:LY96:LPS:CD14 - Rattus norvegicus [Reaction:R-RNO-2201341] Endocytosis of TRAM (TICAM2) - Rattus norvegicus [Reaction:R-RNO-166168] TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) - Rattus norvegicus [Pathway:R-RNO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Rattus norvegicus [Pathway:R-RNO-166166] MyD88-independent TLR4 cascade - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	8
name	Toll Like Receptor 4 (TLR4) Cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-166016
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-168898] Toll-like Receptor Cascades
(inferredTo)	[Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade

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