Reactome | Endocytosis of TRAM (TICAM2)

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Endocytosis of TRAM (TICAM2) Show undefined attributes

authored	[InstanceEdit:2201346] Shamovsky, V, 2012-04-19
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:876] plasma membrane
created	[InstanceEdit:2201342] Shamovsky, V, 2012-04-19
dbId	2201341
displayName	Endocytosis of TRAM (TICAM2)
edited	[InstanceEdit:2272804] Shamovsky, V, 2012-05-25
eventOf	[Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-166160] MyrG-p-S16-TICAM2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:975473] Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling [LiteratureReference:975477] TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta [LiteratureReference:2206266] Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling [LiteratureReference:8877178] Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Endocytosis of TRAM (TICAM2)
orthologousEvent	[Reaction:R-MMU-2201341] Endocytosis of TRAM (TICAM2) - Mus musculus [Reaction:R-DRE-2201341] Endocytosis of TRAM (TICAM2) - Danio rerio [Reaction:R-SSC-2201341] Endocytosis of TRAM (TICAM2) - Sus scrofa [Reaction:R-BTA-2201341] Endocytosis of TRAM (TICAM2) - Bos taurus [Reaction:R-CFA-2201341] Endocytosis of TRAM (TICAM2) - Canis familiaris [Reaction:R-RNO-2201341] Endocytosis of TRAM (TICAM2) - Rattus norvegicus
output	[EntityWithAccessionedSequence:R-HSA-2201336] MyrG-p-S16-TICAM2 [endosome membrane]
regulatedBy	[NegativeRegulation:R-HSA-8877176] Negative regulation by 'PTPN4 [cytosol]'
regulationReference	[RegulationReference:9641901] Negative regulation by 'PTPN4 [cytosol]' Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2272817] D'Eustachio, P, 2012-05-25 [InstanceEdit:2581520] Granucci, Francesca, Zanoni, Ivan, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2201341
summation	[Summation:2206263] TRIF-related adapter molecule (TRAM or also known as TICAM2)...
updateTrackers	[UpdateTracker:9782829] Update Tracker - [Reaction:2201341] Endocytosis of TRAM (TICAM2) - v58:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9787319] Update Tracker - [Reaction:2201341] Endocytosis of TRAM (TICAM2) - v45:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782829] Update Tracker - [Reaction:2201341] Endocytosis of TRAM (TICAM2) - v58:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9787319] Update Tracker - [Reaction:2201341] Endocytosis of TRAM (TICAM2) - v45:[modifyText]
(hasEvent)	[Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade

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