Reactome | Rev-mediated nuclear export of HIV RNA

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Rev-mediated nuclear export of HIV RNA Show undefined attributes

authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
created	[InstanceEdit:165042] Matthews, L, 2005-07-26 23:04:06
crossReference	[DatabaseIdentifier:12819495] BioModels Database:BIOMD0000000192 [DatabaseIdentifier:12020765] Mondo:0005109
dbId	165054
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Rev-mediated nuclear export of HIV RNA
edited	[InstanceEdit:180928] Matthews, L, 2006-06-07 20:09:58
eventOf	[Pathway:R-HSA-162599] Late Phase of HIV Life Cycle - Homo sapiens
figure	[Figure:167731] /figures/RNA_transport.jpg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-165027] Rev molecules assemble onto the RRE RNA sequence through their ARM sequence - Homo sapiens [Reaction:R-HSA-165033] Multimerization of Rev - Homo sapiens [Reaction:R-HSA-180885] Rev multimer-bound HIV mRNA associates with Crm1 - Homo sapiens [Reaction:R-HSA-180687] Conversion of Ran-GDP to Ran-GTP - Homo sapiens [Reaction:R-HSA-165034] Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP - Homo sapiens [Reaction:R-HSA-165043] Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC - Homo sapiens [Reaction:R-HSA-165047] Translocation of nuclear RNA transport complex to cytoplasm - Homo sapiens [Reaction:R-HSA-180739] Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex - Homo sapiens [Reaction:R-HSA-165028] Release of the HIV mRNA and Crm1 from Rev in the cytoplasm - Homo sapiens [Reaction:R-HSA-165055] Hydrolysis of Ran:GTP to Ran:GDP - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-09-30
literatureReference	[LiteratureReference:165039] HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs [LiteratureReference:165620] Retroviruses as model systems for the study of nuclear RNA export [LiteratureReference:165623] Nuclear mRNA export: insights from virology
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Rev-mediated nuclear export of HIV RNA
precedingEvent	[Pathway:R-HSA-167172] Transcription of the HIV genome - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192365] Kumar, A, 2007-01-31 22:47:49
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-165054
summation	[Summation:165618] The HIV-1 genome contains 9 genes encoded by a single trans...
updateTrackers	[UpdateTracker:9792487] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v20:[addHasEvent] [UpdateTracker:9790557] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v33:[addHasEvent, updateContainedRLE] [UpdateTracker:9788077] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v44:[updateContainedRLE] [UpdateTracker:9784455] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v54:[updateContainedRLE]

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[UpdateTracker:9792487] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v20:[addHasEvent]
[UpdateTracker:9790557] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v33:[addHasEvent, updateContainedRLE]
[UpdateTracker:9788077] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v44:[updateContainedRLE]
[UpdateTracker:9784455] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v54:[updateContainedRLE]

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