Reactome | Nef mediated downregulation of MHC class I complex cell surface expression

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Nef mediated downregulation of MHC class I complex cell surface expression Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
created	[InstanceEdit:164941] Gillespie, ME, 2005-07-22 21:03:59
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	164940
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Nef mediated downregulation of MHC class I complex cell surface expression
eventOf	[Pathway:R-HSA-164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160451] negative regulation of defense response to virus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-182243] Formation of MHC I:Nef Complex - Homo sapiens [Reaction:R-HSA-182279] Formation of MHC I:Nef:AP-1:PACS-1 Complex - Homo sapiens [Reaction:R-HSA-182286] Transport of MHC I:Nef:AP-1:PACS-1 Complex - Homo sapiens [BlackBoxEvent:R-HSA-182263] Degradation of MHC I Complex - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2013-03-31
literatureReference	[LiteratureReference:182251] Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein [LiteratureReference:200839] Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules [LiteratureReference:200841] Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking [LiteratureReference:200881] HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway [LiteratureReference:200893] HIV-1 Nef impairs MHC class II antigen presentation and surface expression
maxDepth	2
modified	[InstanceEdit:9953541] Gillespie, Marc E, 2025-06-03
name	Nef mediated downregulation of MHC class I complex cell surface expression
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-164940
summation	[Summation:182396] Down-regulation of MHC class I involves Nef-mediated connect...
updateTrackers	[UpdateTracker:9787654] Update Tracker - [Pathway:164940] Nef mediated downregulation of MHC class I complex cell surface expression - v44:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9787654] Update Tracker - [Pathway:164940] Nef mediated downregulation of MHC class I complex cell surface expression - v44:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

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