Reactome | Down-regulation of MHC class I involves Nef-mediated connect...

Schema > Summation > Entries

created	[InstanceEdit:182382] Gillespie, ME, 2006-07-07 16:32:59
dbId	182396
displayName	Down-regulation of MHC class I involves Nef-mediated connect...
literatureReference	[LiteratureReference:182385] HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes [LiteratureReference:182307] HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
schemaClass	Summation
text	Down-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sorting pathway. Down-regulation of MHC I protects HIV-infected cells from host CTL response.

(summation)

Cite Us!