Reactome | Formation of MHC I:Nef:AP-1:PACS-1 Complex

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Formation of MHC I:Nef:AP-1:PACS-1 Complex Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:182282] Gillespie, ME, 2006-07-06 21:32:37
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	182279
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Formation of MHC I:Nef:AP-1:PACS-1 Complex
eventOf	[Pathway:R-HSA-164940] Nef mediated downregulation of MHC class I complex cell surface expression - Homo sapiens
followingEvent	[Reaction:R-HSA-182286] Transport of MHC I:Nef:AP-1:PACS-1 Complex - Homo sapiens
input	[Complex:R-HSA-167717] AP-1 Complex [cytosol] [Complex:R-HSA-182256] Nef:class I MHC complex [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-167634] PACS1 [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182307] HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of MHC I:Nef:AP-1:PACS-1 Complex
output	[Complex:R-HSA-182373] Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane]
precedingEvent	[Reaction:R-HSA-182243] Formation of MHC I:Nef Complex - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-182279
summation	[Summation:182401] The complex formed by Nef and the major histocompatibility c...

Referrals

(precedingEvent)	[Reaction:R-HSA-182286] Transport of MHC I:Nef:AP-1:PACS-1 Complex
(hasEvent)	[Pathway:R-HSA-164940] Nef mediated downregulation of MHC class I complex cell surface expression

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