Nef mediated downregulation of MHC class I complex cell surface expression

Stable Identifier
R-HSA-164940
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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Nef mediated downregulation of MHC class I complex cell surface expression
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Down-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sorting pathway. Down-regulation of MHC I protects HIV-infected cells from host CTL response.
Literature References
PubMed ID Title Journal Year
11593029 HIV-1 Nef impairs MHC class II antigen presentation and surface expression

Stumptner-Cuvelette, P, Morchoisne, S, Dugast, M, Le Gall, S, Raposo, G, Schwartz, O, Benaroch, P

Proc Natl Acad Sci U S A 2001
12414957 Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking

Williams, M, Roeth, JF, Kasper, MR, Fleis, RI, Przybycin, CG, Collins, KL

J Virol 2002
8612235 Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein

Schwartz, O, Marechal, V, Le Gall, S, Lemonnier, F, Heard, JM

Nat Med 1996
9586638 Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

Le Gall, S, Erdtmann, L, Benichou, S, Berlioz-Torrent, C, Liu, L, Benarous, R, Heard, JM, Schwartz, O

Immunity 1998
12526811 HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway

Blagoveshchenskaya, AD, Thomas, L, Feliciangeli, SF, Hung, CH, Thomas, G

Cell 2002
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
negative regulation of defense response to virus (0050687)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
Mondo
Authored
Gillespie, ME  (2007-07-25)
Reviewed
Skowronski, J  (2007-08-07)
Created
Gillespie, ME  (2005-07-23)
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