Reactome | ChREBP activates metabolic gene expression

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ChREBP activates metabolic gene expression Show undefined attributes

authored	[InstanceEdit:164203] Gopinathrao, G, 2005-05-12 21:32:40
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
dbId	163765
deleted	[Deleted:622331] Deletion of instances: 163699, 163667
displayName	ChREBP activates metabolic gene expression
doi	10.3180/R-HSA-163765.5
eventOf	[Pathway:R-HSA-163685] Integration of energy metabolism - Homo sapiens
figure	[Figure:164076] /figures/chrebp1.jpg
goBiologicalProcess	[GO_BiologicalProcess:3323] positive regulation of metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-163666] Formation of ChREBP:MLX heterodimer - Homo sapiens [Reaction:R-HSA-9856539] MLXIPL:MLX binds PKLR gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-163669] Transcriptional activation of PKLR gene by ChREBP:MLX - Homo sapiens [Reaction:R-HSA-9856549] MLXIPL:MLX binds ACLY gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - Homo sapiens [Reaction:R-HSA-9856546] MLXIPL:MLX binds FASN gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-163733] Transcriptional activation of FASN monomer gene by ChREBP:MLX - Homo sapiens [Reaction:R-HSA-9856550] MLXIPL:MLX binds ACACA gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-163743] Transcriptional activation of ACACA by ChREBP:MLX - Homo sapiens [Reaction:R-HSA-9856548] MLXIPL:MLX binds ACACB gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9856605] Transcriptional activation of ACACB by ChREBP:MLX - Homo sapiens [Reaction:R-HSA-9856604] MLXIPL:MLX binds AGPAT1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-163748] Transcriptional activation of AGPAT1 by ChREBP:MLX - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-12-10
literatureReference	[LiteratureReference:164097] Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein [LiteratureReference:164205] Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis [LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
maxDepth	2
modified	[InstanceEdit:9924190] D'Eustachio, Peter, 2024-10-08
name	ChREBP activates metabolic gene expression
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9860914] Hill, David P, 2024-02-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-163765
summation	[Summation:164216] ChREBP (Carbohydrate Response Element Binding Protein) is a ...
updateTrackers	[UpdateTracker:9864179] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v88:[addHasEvent, updateContainedRLE] [UpdateTracker:9781341] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v61:[updateContainedRLE] [UpdateTracker:9777816] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v69:[updateContainedRLE] [UpdateTracker:9777494] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v71:[updateContainedRLE] [UpdateTracker:9790521] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v33:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9911016] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v89:[updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9864179] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v88:[addHasEvent, updateContainedRLE] [UpdateTracker:9781341] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v61:[updateContainedRLE] [UpdateTracker:9777816] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v69:[updateContainedRLE] [UpdateTracker:9777494] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v71:[updateContainedRLE] [UpdateTracker:9790521] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v33:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9911016] Update Tracker - [Pathway:163765] ChREBP activates metabolic gene expression - v89:[updateContainedRLE]
(replacementInstances)	[Deleted:622331] Deletion of instances: 163699, 163667
(hasEvent)	[Pathway:R-HSA-163685] Integration of energy metabolism

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