Reactome | Transcriptional activation of AGPAT1 by ChREBP:MLX

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Transcriptional activation of AGPAT1 by ChREBP:MLX Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
dbId	163748
displayName	Transcriptional activation of AGPAT1 by ChREBP:MLX
eventOf	[Pathway:R-HSA-163765] ChREBP activates metabolic gene expression - Homo sapiens
followingEvent	[Reaction:R-HSA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
input	[EntityWithAccessionedSequence:R-HSA-9856495] AGPAT1 gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. [LiteratureReference:8984798] ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver [LiteratureReference:8984350] A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription
maxDepth	1
modified	[InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
name	Transcriptional activation of AGPAT1 by ChREBP:MLX
output	[EntityWithAccessionedSequence:R-HSA-61803] AGPAT1 [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9856604] MLXIPL:MLX binds AGPAT1 gene promoter - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-164416] Positive gene expression regulation by 'MLXIPL:MLX: AGPAT1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9857470] Positive gene expression regulation by 'MLXIPL:MLX: AGPAT1 gene [nucleoplasm]' Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9860914] Hill, David P, 2024-02-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-163748
summation	[Summation:179359] The AGPAT1 (1-acyl-sn-glycerol-3-phosphate acyltransferase a...
updateTrackers	[UpdateTracker:9790624] Update Tracker - [BlackBoxEvent:163748] Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX - v33:[add_removeRegulator] [UpdateTracker:9781484] Update Tracker - [BlackBoxEvent:163748] Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX - v61:[addLiteratureReference, modifyText] [UpdateTracker:9864285] Update Tracker - [BlackBoxEvent:163748] Transcriptional activation of AGPAT1 by ChREBP:MLX - v88:[addInput, addLiteratureReference, add_removeRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790624] Update Tracker - [BlackBoxEvent:163748] Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX - v33:[add_removeRegulator] [UpdateTracker:9781484] Update Tracker - [BlackBoxEvent:163748] Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX - v61:[addLiteratureReference, modifyText] [UpdateTracker:9864285] Update Tracker - [BlackBoxEvent:163748] Transcriptional activation of AGPAT1 by ChREBP:MLX - v88:[addInput, addLiteratureReference, add_removeRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-163765] ChREBP activates metabolic gene expression
(precedingEvent)	[Reaction:R-HSA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT)