Reactome | Formation of ChREBP:MLX heterodimer

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Formation of ChREBP:MLX heterodimer Show undefined attributes

catalystActivity	[CatalystActivity:9857007] DNA-binding transcription factor activity of MLX [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9857001] DNA-binding transcription factor activity of MLX [nucleoplasm] Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:163686] Gopinathrao, G, 2005-05-04 21:08:21
dbId	163666
displayName	Formation of ChREBP:MLX heterodimer
eventOf	[Pathway:R-HSA-163765] ChREBP activates metabolic gene expression - Homo sapiens
followingEvent	[Reaction:R-HSA-9856548] MLXIPL:MLX binds ACACB gene promoter - Homo sapiens [Reaction:R-HSA-9856550] MLXIPL:MLX binds ACACA gene promoter - Homo sapiens [Reaction:R-HSA-9856546] MLXIPL:MLX binds FASN gene promoter - Homo sapiens [Reaction:R-HSA-9856549] MLXIPL:MLX binds ACLY gene promoter - Homo sapiens [Reaction:R-HSA-9856539] MLXIPL:MLX binds PKLR gene promoter - Homo sapiens [Reaction:R-HSA-9856604] MLXIPL:MLX binds AGPAT1 gene promoter - Homo sapiens
inferredFrom	[Reaction:R-MMU-164189] Formation of mChREBP:mMlx complex - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-163695] MLX [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-163683] MLXIPL [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
maxDepth	1
modified	[InstanceEdit:9861201] D'Eustachio, Peter, 2024-02-14
name	Formation of ChREBP:MLX heterodimer
output	[Complex:R-HSA-163700] MLXIPL:MLX [nucleoplasm]
precedingEvent	[Reaction:R-HSA-164056] Dephosphorylation of pChREBP (Ser 556) by PP2A - Homo sapiens [Reaction:R-HSA-163688] Dephosphorylation of pChREBP (Thr 666) by PP2A - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9860914] Hill, David P, 2024-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-163666
summation	[Summation:178770] Dephosphorylation of ChREBP protein enables it to enter the ...
updateTrackers	[UpdateTracker:9863970] Update Tracker - [Reaction:163666] Formation of ChREBP:MLX heterodimer - v88:[addCatalystActivity, addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9863970] Update Tracker - [Reaction:163666] Formation of ChREBP:MLX heterodimer - v88:[addCatalystActivity, addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-163765] ChREBP activates metabolic gene expression
(precedingEvent)	[Reaction:R-HSA-9856548] MLXIPL:MLX binds ACACB gene promoter [Reaction:R-HSA-9856550] MLXIPL:MLX binds ACACA gene promoter [Reaction:R-HSA-9856546] MLXIPL:MLX binds FASN gene promoter [Reaction:R-HSA-9856549] MLXIPL:MLX binds ACLY gene promoter [Reaction:R-HSA-9856539] MLXIPL:MLX binds PKLR gene promoter [Reaction:R-HSA-9856604] MLXIPL:MLX binds AGPAT1 gene promoter
(inferredTo)	[Reaction:R-MMU-164189] Formation of mChREBP:mMlx complex