Reactome | MLXIPL:MLX binds AGPAT1 gene promoter

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MLXIPL:MLX binds AGPAT1 gene promoter Show undefined attributes

authored	[InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20
catalystActivity	[CatalystActivity:9856544] DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9857478] DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20
dbId	9856604
displayName	MLXIPL:MLX binds AGPAT1 gene promoter
edited	[InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19
eventOf	[Pathway:R-HSA-163765] ChREBP activates metabolic gene expression - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-163748] Transcriptional activation of AGPAT1 by ChREBP:MLX - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9856495] AGPAT1 gene [nucleoplasm] 2 × [Complex:R-HSA-163700] MLXIPL:MLX [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. [LiteratureReference:8984798] ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver [LiteratureReference:8984350] A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription
maxDepth	1
modified	[InstanceEdit:9863550] D'Eustachio, Peter, 2024-03-01
name	MLXIPL:MLX binds AGPAT1 gene promoter
output	[Complex:R-HSA-9856607] MLXIPL:MLX: AGPAT1 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-163666] Formation of ChREBP:MLX heterodimer - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9860914] Hill, David P, 2024-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9856604
summation	[Summation:9857484] As part of the physiological response to high dietary carboh...

Referrals

(hasEvent)	[Pathway:R-HSA-163765] ChREBP activates metabolic gene expression
(precedingEvent)	[BlackBoxEvent:R-HSA-163748] Transcriptional activation of AGPAT1 by ChREBP:MLX

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