Reactome | Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX

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Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17
dbId	163770
displayName	Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX
eventOf	[Pathway:R-HSA-163765] ChREBP activates metabolic gene expression - Homo sapiens
followingEvent	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
input	[EntityWithAccessionedSequence:R-HSA-9666703] ACLY gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. [LiteratureReference:8984798] ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver [LiteratureReference:8984350] A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription
maxDepth	1
modified	[InstanceEdit:9857474] D'Eustachio, Peter, 2024-01-05
name	Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX
output	[Complex:R-HSA-76188] ACLY tetramer [cytosol]
precedingEvent	[Reaction:R-HSA-9856549] MLXIPL:MLX binds ACLY gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-164421] Positive gene expression regulation by 'MLXIPL:MLX:ACLY gene [nucleoplasm]'
regulationReference	[RegulationReference:9857473] Positive gene expression regulation by 'MLXIPL:MLX:ACLY gene [nucleoplasm]' Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-163770
summation	[Summation:179357] The ACLY (ATP citrate synthase) gene, activated by binding o...
updateTrackers	[UpdateTracker:9781421] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v61:[addLiteratureReference] [UpdateTracker:9864145] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v88:[addLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9777805] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v69:[add_removeOutput] [UpdateTracker:9777422] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v71:[addInput] [UpdateTracker:9790470] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v33:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9781421] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v61:[addLiteratureReference] [UpdateTracker:9864145] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v88:[addLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9777805] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v69:[add_removeOutput] [UpdateTracker:9777422] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v71:[addInput] [UpdateTracker:9790470] Update Tracker - [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX - v33:[add_removeRegulator]
(hasEvent)	[Pathway:R-HSA-163765] ChREBP activates metabolic gene expression
(precedingEvent)	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA

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