Reactome | UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG

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UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG Show undefined attributes

authored	[InstanceEdit:159184] Jassal, B, 2005-02-23 15:02:50
catalystActivity	[CatalystActivity:9704996] glucuronosyltransferase activity of UGT1A4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:159184] Jassal, B, 2005-02-23 15:02:50
dbId	159194
diseaseReaction	[FailedReaction:R-HSA-5604954] Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL - Homo sapiens
displayName	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG
edited	[InstanceEdit:827350] Jassal, B, 2010-05-27
eventOf	[Pathway:R-HSA-156588] Glucuronidation - Homo sapiens [Pathway:R-HSA-189483] Heme degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-159179] UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG - Homo sapiens [BlackBoxEvent:R-HSA-9661446] BMG, BDG translocates from ER lumen to cytosol - Homo sapiens [Reaction:R-HSA-9632038] UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:21565] bilirubin conjugation
input	[SimpleEntity:R-ALL-159151] BIL [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-174384] UDP-GlcA [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:159153] Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man [LiteratureReference:5605005] A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini [LiteratureReference:159192] The hepatic microsomal formation of bilirubin diglucuronide [LiteratureReference:159163] Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography [LiteratureReference:159173] Microsomal UDP-glucuronyltransferase-catalyzed bilirubin diglucuronide formation in human liver [LiteratureReference:159193] Bilirubin conjugates in bile of man and rat in the normal state and in liver disease
maxDepth	1
modified	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
name	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP
orthologousEvent	[Reaction:R-RNO-159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG - Rattus norvegicus [Reaction:R-MMU-159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG - Mus musculus
output	[SimpleEntity:R-ALL-159160] BMG [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-158602] UDP [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen - Homo sapiens [BlackBoxEvent:R-HSA-189381] BIL translocates from the cytosol to the ER lumen - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:699799] D'Eustachio, P, 2010-05-08
revised	[InstanceEdit:5603394] Jassal, Bijay, 2014-07-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-159194
summation	[Summation:159166] Bilirubin (BIL) is a breakdown product of heme. Its accumula...
updateTrackers	[UpdateTracker:9776534] Update Tracker - [Reaction:159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG - v75:[addLiteratureReference, add_removeCatalystActivity, modifyText] [UpdateTracker:9786236] Update Tracker - [Reaction:159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG - v50:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776534] Update Tracker - [Reaction:159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG - v75:[addLiteratureReference, add_removeCatalystActivity, modifyText] [UpdateTracker:9786236] Update Tracker - [Reaction:159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG - v50:[add_removeLiteratureReference, modifyText]
(normalReaction)	[FailedReaction:R-HSA-5604954] Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL
(hasEvent)	[Pathway:R-HSA-156588] Glucuronidation [Pathway:R-HSA-189483] Heme degradation
(precedingEvent)	[Reaction:R-HSA-159179] UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG [BlackBoxEvent:R-HSA-9661446] BMG, BDG translocates from ER lumen to cytosol [Reaction:R-HSA-9632038] UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG

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