Bilirubin (BIL) is a breakdown product of heme. Its accumula...

created [InstanceEdit:159184] Jassal, B, 2005-02-23 15:02:50
dbId 159166
displayName Bilirubin (BIL) is a breakdown product of heme. Its accumula...
modified [InstanceEdit:9704995] Jassal, Bijay, 2020-10-19
schemaClass Summation
text Bilirubin (BIL) is a breakdown product of heme. Its accumulation in the blood can be fatal. It is highly lipophilic and thus requires conjugation to become more water soluble to aid excretion. Both UGT1A1 tetramer and UGT1A4 can transfer glucuronic acid (GlcA) to bilirubin to form either its monoglucuronide (BMG) or diglucuronide (BDG) conjugates (Bosma et al. 1994, Ritter et al. 1992, Peters & Jansen 1986, Gorden et al. 1983, Choudhury et al. 1981, Fevery et al. 1971).
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