Reactome | UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG

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UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG Show undefined attributes

catalystActivity	[CatalystActivity:9995063] glucuronosyltransferase activity of UGT1A4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9995067
displayName	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG
eventOf	[Pathway:R-MMU-156588] Glucuronidation - Mus musculus [Pathway:R-MMU-189483] Heme degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-159179] UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG - Mus musculus [Reaction:R-MMU-9632038] UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:21565] bilirubin conjugation
inferredFrom	[Reaction:R-HSA-159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG - Homo sapiens
input	[SimpleEntity:R-ALL-159151] BIL [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-174384] UDP-GlcA [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP
output	[SimpleEntity:R-ALL-159160] BMG [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-158602] UDP [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-MMU-174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-159194
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-156588] Glucuronidation [Pathway:R-MMU-189483] Heme degradation
(precedingEvent)	[Reaction:R-MMU-159179] UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG [Reaction:R-MMU-9632038] UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG
(inferredTo)	[Reaction:R-HSA-159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG

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