Reactome | BIL translocates from the cytosol to the ER lumen

Schema > BlackBoxEvent > Entries

BIL translocates from the cytosol to the ER lumen Show undefined attributes

category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:189383] Jassal, Bijay, 2006-11-20
dbId	189381
displayName	BIL translocates from the cytosol to the ER lumen
eventOf	[Pathway:R-HSA-189483] Heme degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG - Homo sapiens [Reaction:R-HSA-9632039] UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG - Homo sapiens
input	[SimpleEntity:R-ALL-189386] BIL [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984856] [Intracellular bilirubin transport and the membrane of the hepatic endoplasmic reticulum: new aspects in the development of transitory bilirubinemia of the newborn] [LiteratureReference:9661503] Extensive protein-protein interactions involving UDP-glucuronosyltransferase (UGT) 2B7 in human liver microsomes
maxDepth	1
modified	[InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
name	BIL translocates from the cytosol to the ER lumen
negativePrecedingEvent	[NegativePrecedingEvent:9955841] BLVRA:Zn2+, BLVRB reduce BV to BIL [NegativePrecedingEvent:9955862] SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) [NegativePrecedingEvent:9955856] SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) [NegativePrecedingEvent:9955857] SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
output	[SimpleEntity:R-ALL-159151] BIL [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:R-HSA-9663492] BIL dissociates from GSTA1, FABP1 - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9661807] Jassal, Bijay, 2019-09-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-189381
summation	[Summation:189397] The enzyme which catalyzes the conjugation of bilirubin (UGT...
updateTrackers	[UpdateTracker:9777477] Update Tracker - [BlackBoxEvent:189381] BIL translocates from the cytosol to the ER lumen - v71:[addLiteratureReference, modifyText] [UpdateTracker:9781457] Update Tracker - [BlackBoxEvent:189381] BIL translocates from the cytosol to the ER lumen - v61:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9777477] Update Tracker - [BlackBoxEvent:189381] BIL translocates from the cytosol to the ER lumen - v71:[addLiteratureReference, modifyText] [UpdateTracker:9781457] Update Tracker - [BlackBoxEvent:189381] BIL translocates from the cytosol to the ER lumen - v61:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-189483] Heme degradation
(precedingEvent)	[Reaction:R-HSA-159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG [Reaction:R-HSA-9632039] UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG