Reactome | UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG

UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG

Stable Identifier

R-HSA-159194

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP

ReviewStatus

5/5

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UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG

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Bilirubin (BIL) is a breakdown product of heme. Its accumulation in the blood can be fatal. It is highly lipophilic and thus requires conjugation to become more water soluble to aid excretion. Both UGT1A1 tetramer and UGT1A4 can transfer glucuronic acid (GlcA) to bilirubin to form either its monoglucuronide (BMG) or diglucuronide (BDG) conjugates (Bosma et al. 1994, Ritter et al. 1992, Peters & Jansen 1986, Gorden et al. 1983, Choudhury et al. 1981, Fevery et al. 1971).

Literature References

PubMed ID	Title	Journal	Year
4639028	Bilirubin conjugates in bile of man and rat in the normal state and in liver disease Fevery, J, Van, Damme B, Michiels, R, De Groote, J, Heirwegh, KP	J Clin Invest	1972
6654901	The hepatic microsomal formation of bilirubin diglucuronide Gordon, ER, Sommerer, U, Goresky, CA	J Biol Chem	1983
6796486	Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography Chowdhury, JR, Chowdhury, NR, Wu, G, Shouval, R, Arias, IM	Hepatology	1981
1339448	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini Ritter, JK, Chen, F, Sheen, YY, Tran, HM, Kimura, S, Yeatman, MT, Owens, IS	J. Biol. Chem.	1992
3082969	Microsomal UDP-glucuronyltransferase-catalyzed bilirubin diglucuronide formation in human liver Peters, WH, Jansen, PL	J Hepatol	1986
8027054	Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man Bosma, PJ, Seppen, J, Goldhoorn, B, Bakker, C, Oude, Elferink R, Chowdhury, JR, Chowdhury, NR, Jansen, PL	J Biol Chem	1994