NEXT2 is cleaved to produce NICD2

Stable Identifier
Reaction [transition]
Homo sapiens
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NEXT2 fragment of NOTCH2 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD2 into the cytosol (Saxena et al. 2001, De Strooper et al. 1999, Schroeter et al. 1998, Fortini 2002).
Literature References
PubMed ID Title Journal Year
24842903 Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins

Groot, AJ, Habets, R, Vooijs, M, Saftig, P, Hodin, CM, Theys, J, Reiss, K, Yahyanejad, S

Mol. Cell. Biol. 2014
11518718 Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

Saxena, MT, Kopan, R, Schroeter, EH, Mumm, JS

J Biol Chem 2001
12209127 Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

Fortini, ME

Nat Rev Mol Cell Biol 2002
9620803 Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Kopan, R, Kisslinger, JA, Schroeter, EH

Nature 1998
10206645 A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Wolfe, MS, Kopan, R, De Strooper, B, Schrijvers, V, Schroeter, EH, Cupers, P, Goate, A, Saftig, P, Craessaerts, K, Ray, WJ, Mumm, JS, Annaert, W

Nature 1999
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Inferred From
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