Reactome | aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Schema > CatalystActivity > Entries

activeUnit	[DefinedSet:R-HSA-9013333] Presenilin [plasma membrane] - Homo sapiens
activity	[GO_MolecularFunction:1933] aspartic-type endopeptidase activity
catalyzedEvent	[Reaction:R-HSA-2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants - Homo sapiens [Reaction:R-NUL-2197556] Gamma-secretase complex cleaves mNEXT2 - Homo sapiens [Reaction:R-HSA-157640] NEXT2 is cleaved to produce NICD2 - Homo sapiens [BlackBoxEvent:R-HSA-9017817] Gamma-secretase cleaves YBX1:NOTCH3 - Homo sapiens [Reaction:R-NUL-9604300] Gamma-secretase cleaves Notch4 - Homo sapiens [Reaction:R-HSA-9604294] Gamma-secretase cleaves NOTCH4 - Homo sapiens [Reaction:R-HSA-9013361] NEXT3 is cleaved to produce NICD3 - Homo sapiens [Reaction:R-HSA-157353] NEXT1 is cleaved to produce NICD1 - Homo sapiens
created	[InstanceEdit:157354] Jassal, B, 2004-12-21 14:32:26
dbId	157355
displayName	aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
physicalEntity	[Complex:R-HSA-157343] gamma-secretase complex [plasma membrane]
schemaClass	CatalystActivity

(catalystActivity)