Reactome | DVL recruits GSK3beta:AXIN1 to the receptor complex

DVL recruits GSK3beta:AXIN1 to the receptor complex

Stable Identifier

R-HSA-1504186

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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DVL recruits GSK3beta:AXIN1 to the receptor complex

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The DIX domains of DVL and AXIN interact and this interaction brings GSK3beta:AXIN1 to the receptor complex (Schwarz-Romond et al, 2007). Subsequently, sequential phosphorylation of LRP5/6 by GSK3beta and CSNK1 generates high affinity AXIN binding sites and functions to amplify recruitment to the membrane (Mao et al, 2001; Zeng et al, 2008). In some models, this recruitment of AXIN to the membrane is facilitated by clustering of DVL and/or LRP5/6 into a 'signalosome' (Bilic et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
11336703	Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway Li, L, Kimelman, D, Takada, S, Wu, D, Yuan, H, Farr GH, 3rd, Flynn, C, Pan, W, Liu, B, Wang, J, Mao, J	Mol Cell	2001
18077588	Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions Almeida, K, Woodgett, J, Hsieh, JC, Harada, Y, Tamai, K, Huang, H, Wynshaw-Boris, A, Wang, J, Zhang, X, Doble, B, Yokota, C, Zeng, X, He, X	Development	2008
17529994	The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization Kikuchi, A, Shibata, N, Higuchi, Y, Schwarz-Romond, T, Bienz, M, Fiedler, M, Butler, PJ	Nat. Struct. Mol. Biol.	2007
17569865	Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation Niehrs, C, Cruciat, CM, Bienz, M, Zimmermann, T, Huang, YL, Bilic, J, Davidson, G	Science	2007