DVL recruits GSK3beta:AXIN1 to the receptor complex

Stable Identifier
R-HSA-1504186
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The DIX domains of DVL and AXIN interact and this interaction brings GSK3beta:AXIN1 to the receptor complex (Schwarz-Romond et al, 2007). Subsequently, sequential phosphorylation of LRP5/6 by GSK3beta and CSNK1 generates high affinity AXIN binding sites and functions to amplify recruitment to the membrane (Mao et al, 2001; Zeng et al, 2008). In some models, this recruitment of AXIN to the membrane is facilitated by clustering of DVL and/or LRP5/6 into a 'signalosome' (Bilic et al, 2007).

Literature References
PubMed ID Title Journal Year
18077588 Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

Zeng, X, Huang, H, Tamai, K, Zhang, X, Harada, Y, Yokota, C, Almeida, K, Wang, J, Doble, B, Woodgett, J, Wynshaw-Boris, A, Hsieh, JC, He, X

Development 2008
11336703 Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

Mao, J, Wang, J, Liu, B, Pan, W, Farr GH, 3rd, Flynn, C, Yuan, H, Takada, S, Kimelman, D, Li, L, Wu, D

Mol Cell 2001
17529994 The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

Schwarz-Romond, T, Fiedler, M, Shibata, N, Butler, PJ, Kikuchi, A, Higuchi, Y, Bienz, M

Nat. Struct. Mol. Biol. 2007
17569865 Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

Bilic, J, Huang, YL, Davidson, G, Zimmermann, T, Cruciat, CM, Bienz, M, Niehrs, C

Science 2007
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