Reactome | DVL recruits GSK3beta:AXIN1 to the receptor complex

Schema > Reaction > Entries

DVL recruits GSK3beta:AXIN1 to the receptor complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10596285
displayName	DVL recruits GSK3beta:AXIN1 to the receptor complex
eventOf	[Pathway:R-DRE-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Danio rerio
inferredFrom	[Reaction:R-HSA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Homo sapiens
input	[Complex:R-DRE-1504204] GSK3B:AXIN1 [cytosol] [Complex:R-DRE-1504192] WNT:FZD:LRP5/6:DVL [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	DVL recruits GSK3beta:AXIN1 to the receptor complex
output	[Complex:R-DRE-1504184] WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1504186
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane
(precedingEvent)	[Reaction:R-DRE-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
(inferredTo)	[Reaction:R-HSA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex

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