PC is hydrolyzed to 1-acyl LPC by PLA2[5]

Stable Identifier
Reaction [transition]
Homo sapiens
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At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed and has one of its acyl chains cleaved off by a phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010, Clarke et al. 1991, Sharp et al. 1994, Song et al. 1999, Chiba et al. 2004), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC

J Biol Chem 2010
9417066 Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity

Larsson, PK, Kennedy, BP, Claesson, HE

J Biol Chem 1998
9705332 A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2

Song, C, Chang, XJ, Kriz, RW, Knopf, JL, Underwood, KW, Lin, LL

J Biol Chem 1998
15944408 Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)

Waku, K, Nakanishi, H, Yamashita, A, Kawagishi, N, Kamata, R, Sugiura, T, Suzuki, H

J Biochem 2005
10092647 Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1

Wang, X, Nowatzke, W, Ramanadham, S, Ma, Z, Turk, J

J Biol Chem 1999
10085124 Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2

Sharp, JD, Pickard, RT, Kramer, RM, Strifler, BA

J Biol Chem 1999
19019078 The identification of a phospholipase B precursor in human neutrophils

Venge, P, Zhao, L, Larsson, A, Xu, S

FEBS J 2009
19501189 Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

Waku, K, Tanaka, K, Kumazawa, T, Yamashita, A, Kamata, R, Sugiura, T, Koga, H, Suzuki, N

Biochim Biophys Acta 2009
18614531 Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)

Duncan, RE, Ahmadian, M, Jaworski, K, Sarkadi-Nagy, E, Sul, HS

J Biol Chem 2008
10358058 Molecular characterization of cytosolic phospholipase A2-beta

Proia, MS, Song, C, Bean, KM, Kriz, RW, Chang, XJ, Knopf, JL

J Biol Chem 1999
1904318 A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

Ramesha, CS, Kriz, RW, Knopf, JL, Lin, AY, Lin, LL, Clark, JD, Milona, N, Sultzman, LA

Cell 1991
10336645 The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene

Kennedy, BP, Larsson Forsell, PK, Claesson, HE

Eur J Biochem 1999
14709560 Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin

Mitsui, H, Seishima, M, Wakimoto, K, Imai, Y, Okubo, K, Kawasaki, S, Chiba, H, Torii, H, Michibata, H

J Biol Chem 2004
8083230 Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2

Pickard, RT, Sharp, JD, Brems, DN, Miller, JR, Manetta, JV, Strifler, BA, Roberts, EF, Kovacevic, S, Varshavsky, AD, Chiou, XG

J Biol Chem 1994
Catalyst Activity

phospholipase A2 activity of PLA2(5) [cytosol]

Orthologous Events
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