Reactome | PC is hydrolyzed to 1-acyl LPC by PLA2[5]

PC is hydrolyzed to 1-acyl LPC by PLA2[5]

Stable Identifier

R-HSA-1482856

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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PC is hydrolyzed to 1-acyl LPC by PLA2[5]

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At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed and has one of its acyl chains cleaved off by a phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010, Clarke et al. 1991, Sharp et al. 1994, Song et al. 1999, Chiba et al. 2004), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.

Literature References

PubMed ID	Title	Journal	Year
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC	J Biol Chem	2010
9417066	Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity Larsson, PK, Kennedy, BP, Claesson, HE	J Biol Chem	1998
9705332	A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2 Song, C, Chang, XJ, Kriz, RW, Knopf, JL, Underwood, KW, Lin, LL	J Biol Chem	1998
15944408	Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) Waku, K, Nakanishi, H, Yamashita, A, Kawagishi, N, Kamata, R, Sugiura, T, Suzuki, H	J Biochem	2005
10092647	Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1 Wang, X, Nowatzke, W, Ramanadham, S, Ma, Z, Turk, J	J Biol Chem	1999
10085124	Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2 Sharp, JD, Pickard, RT, Kramer, RM, Strifler, BA	J Biol Chem	1999
19019078	The identification of a phospholipase B precursor in human neutrophils Venge, P, Zhao, L, Larsson, A, Xu, S	FEBS J	2009
19501189	Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) Waku, K, Tanaka, K, Kumazawa, T, Yamashita, A, Kamata, R, Sugiura, T, Koga, H, Suzuki, N	Biochim Biophys Acta	2009
18614531	Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA) Duncan, RE, Ahmadian, M, Jaworski, K, Sarkadi-Nagy, E, Sul, HS	J Biol Chem	2008
10358058	Molecular characterization of cytosolic phospholipase A2-beta Proia, MS, Song, C, Bean, KM, Kriz, RW, Chang, XJ, Knopf, JL	J Biol Chem	1999
1904318	A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP Ramesha, CS, Kriz, RW, Knopf, JL, Lin, AY, Lin, LL, Clark, JD, Milona, N, Sultzman, LA	Cell	1991
10336645	The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene Kennedy, BP, Larsson Forsell, PK, Claesson, HE	Eur J Biochem	1999
14709560	Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin Mitsui, H, Seishima, M, Wakimoto, K, Imai, Y, Okubo, K, Kawasaki, S, Chiba, H, Torii, H, Michibata, H	J Biol Chem	2004
8083230	Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2 Pickard, RT, Sharp, JD, Brems, DN, Miller, JR, Manetta, JV, Strifler, BA, Roberts, EF, Kovacevic, S, Varshavsky, AD, Chiou, XG	J Biol Chem	1994