Reactome | 2-acyl LPC is acylated to PC by LPCAT

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2-acyl LPC is acylated to PC by LPCAT Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524043] 2-acylglycerol-3-phosphate O-acyltransferase activity of LPCAT [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
crossReference	[DatabaseIdentifier:11880956] Rhea:10332
dbId	1482533
displayName	2-acyl LPC is acylated to PC by LPCAT
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482788] Acyl chain remodelling of PC - Homo sapiens
followingEvent	[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] - Homo sapiens [Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C - Homo sapiens [Reaction:R-HSA-1483142] PC is transphosphatidylated to PG by PLD1-4/6 - Homo sapiens [Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Homo sapiens [Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Homo sapiens [Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1 - Homo sapiens [Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Homo sapiens
input	[SimpleEntity:R-ALL-975614] 2-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482687] Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 [LiteratureReference:1482553] Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7 [LiteratureReference:429001] Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils [LiteratureReference:1482541] Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production [LiteratureReference:1482640] Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells [LiteratureReference:1482581] A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase [LiteratureReference:429002] Identification and characterization of a major liver lysophosphatidylcholine acyltransferase
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	2-acyl LPC is acylated to PC by LPCAT
orthologousEvent	[Reaction:R-PFA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Plasmodium falciparum [Reaction:R-MMU-1482533] 2-acyl LPC is acylated to PC by LPCAT - Mus musculus [Reaction:R-RNO-1482533] 2-acyl LPC is acylated to PC by LPCAT - Rattus norvegicus [Reaction:R-BTA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Bos taurus [Reaction:R-CFA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Canis familiaris [Reaction:R-SSC-1482533] 2-acyl LPC is acylated to PC by LPCAT - Sus scrofa [Reaction:R-XTR-1482533] 2-acyl LPC is acylated to PC by LPCAT - Xenopus tropicalis [Reaction:R-SCE-1482533] 2-acyl LPC is acylated to PC by LPCAT - Saccharomyces cerevisiae [Reaction:R-SPO-1482533] 2-acyl LPC is acylated to PC by LPCAT - Schizosaccharomyces pombe [Reaction:R-DDI-1482533] 2-acyl LPC is acylated to PC by LPCAT - Dictyostelium discoideum [Reaction:R-CEL-1482533] 2-acyl LPC is acylated to PC by LPCAT - Caenorhabditis elegans [Reaction:R-DME-1482533] 2-acyl LPC is acylated to PC by LPCAT - Drosophila melanogaster [Reaction:R-DRE-1482533] 2-acyl LPC is acylated to PC by LPCAT - Danio rerio [Reaction:R-GGA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Gallus gallus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] - Homo sapiens [Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482533
summation	[Summation:1482661] At the endoplasmic reticulum (ER) membrane, lysophospholipid...

Referrals

(precedingEvent)

(hasEvent)

[Pathway:R-HSA-1482788] Acyl chain remodelling of PC

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