Reactome | PC is hydrolyzed to 1-acyl LPC by PLA2[5]

Schema > Reaction > Entries

PC is hydrolyzed to 1-acyl LPC by PLA2[5] Show undefined attributes

catalystActivity	[CatalystActivity:10772408] A2-type glycerophospholipase activity of PLA2(5) [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10772410
displayName	PC is hydrolyzed to 1-acyl LPC by PLA2[5]
eventOf	[Pathway:R-GGA-1482788] Acyl chain remodelling of PC - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Gallus gallus [Reaction:R-GGA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Gallus gallus
inferredFrom	[Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PC is hydrolyzed to 1-acyl LPC by PLA2[5]
output	[SimpleEntity:R-ALL-1524028] 1-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-GGA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Gallus gallus [Reaction:R-GGA-1483219] PC is exchanged with PI by PITPNB - Gallus gallus [Reaction:R-GGA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Gallus gallus [Reaction:R-GGA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1482856
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1482788] Acyl chain remodelling of PC
(precedingEvent)	[Reaction:R-GGA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] [Reaction:R-GGA-1482547] 1-acyl LPC is acylated to PC by LPCAT
(inferredTo)	[Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5]