Reactome | PC is hydrolyzed to 1-acyl LPC by PLA2[6]

PC is hydrolyzed to 1-acyl LPC by PLA2[6]

Stable Identifier

R-HSA-1482816

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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PC is hydrolyzed to 1-acyl LPC by PLA2[6]

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At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed, and has one of its acyl chains cleaved off, by a membrane-associated phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either phospholipase A2 group II alpha (PLA2G2A) (Seihamer et al. 1989, Singer et al. 2002), cytosolic phospholipase A2 group IV gamma (PLA2G4C) (Yamashita et al. 2005, Pickard et al. 1999, Ghomashchi et al. 2010, Yamashita et al. 2009), or calcium-independent phospholipase A2-gamma (PNPLA8) (Murakami et al. 2005, Underwood et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC	J Biol Chem	2010
9705332	A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2 Song, C, Chang, XJ, Kriz, RW, Knopf, JL, Underwood, KW, Lin, LL	J Biol Chem	1998
12359733	Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 Gelb, MH, Le Calvez, C, Ghomashchi, F, Rouault, M, Singer, AG, Sadilek, M, Bollinger, J, Bezzine, S, Lambeau, G, Lazdunski, M, Nguyen, E	J Biol Chem	2002
15944408	Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) Waku, K, Nakanishi, H, Yamashita, A, Kawagishi, N, Kamata, R, Sugiura, T, Suzuki, H	J Biochem	2005
15695510	Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2 Takanezawa, Y, Ishikawa, Y, Kuwata, H, Masuda, S, Kudo, I, Ishii, T, Aoki, J, Arai, H, Sumimoto, H, Murakami, M, Ueda-Semmyo, K, Nakatani, Y, Yoda, E	J Biol Chem	2005
10085124	Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2 Sharp, JD, Pickard, RT, Kramer, RM, Strifler, BA	J Biol Chem	1999
19501189	Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) Waku, K, Tanaka, K, Kumazawa, T, Yamashita, A, Kamata, R, Sugiura, T, Koga, H, Suzuki, N	Biochim Biophys Acta	2009
2925608	Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid Kloss, J, Vadas, P, Miller, JA, Pruzanski, W, Plant, S, Seilhamer, JJ, Johnson, LK	J Biol Chem	1989