PC is hydrolyzed to 1-acyl LPC by PLA2[6]

Stable Identifier
Reaction [transition]
Homo sapiens
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At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed, and has one of its acyl chains cleaved off, by a membrane-associated phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either phospholipase A2 group II alpha (PLA2G2A) (Seihamer et al. 1989, Singer et al. 2002), cytosolic phospholipase A2 group IV gamma (PLA2G4C) (Yamashita et al. 2005, Pickard et al. 1999, Ghomashchi et al. 2010, Yamashita et al. 2009), or calcium-independent phospholipase A2-gamma (PNPLA8) (Murakami et al. 2005, Underwood et al. 1998).

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC

J Biol Chem 2010
9705332 A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2

Song, C, Chang, XJ, Kriz, RW, Knopf, JL, Underwood, KW, Lin, LL

J Biol Chem 1998
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Gelb, MH, Le Calvez, C, Ghomashchi, F, Rouault, M, Singer, AG, Sadilek, M, Bollinger, J, Bezzine, S, Lambeau, G, Lazdunski, M, Nguyen, E

J Biol Chem 2002
15944408 Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)

Waku, K, Nakanishi, H, Yamashita, A, Kawagishi, N, Kamata, R, Sugiura, T, Suzuki, H

J Biochem 2005
15695510 Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2

Takanezawa, Y, Ishikawa, Y, Kuwata, H, Masuda, S, Kudo, I, Ishii, T, Aoki, J, Arai, H, Sumimoto, H, Murakami, M, Ueda-Semmyo, K, Nakatani, Y, Yoda, E

J Biol Chem 2005
10085124 Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2

Sharp, JD, Pickard, RT, Kramer, RM, Strifler, BA

J Biol Chem 1999
19501189 Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

Waku, K, Tanaka, K, Kumazawa, T, Yamashita, A, Kamata, R, Sugiura, T, Koga, H, Suzuki, N

Biochim Biophys Acta 2009
2925608 Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid

Kloss, J, Vadas, P, Miller, JA, Pruzanski, W, Plant, S, Seilhamer, JJ, Johnson, LK

J Biol Chem 1989
Catalyst Activity

phospholipase A2 activity of PLA2(6) [endoplasmic reticulum membrane]

Orthologous Events
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