Reactome | PC is hydrolyzed to 1-acyl LPC by PLA2[6]

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PC is hydrolyzed to 1-acyl LPC by PLA2[6] Show undefined attributes

catalystActivity	[CatalystActivity:11091669] A2-type glycerophospholipase activity of PLA2(6) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11091671
displayName	PC is hydrolyzed to 1-acyl LPC by PLA2[6]
eventOf	[Pathway:R-SCE-1482788] Acyl chain remodelling of PC - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C - Saccharomyces cerevisiae [Reaction:R-SCE-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Saccharomyces cerevisiae [Reaction:R-SCE-1482547] 1-acyl LPC is acylated to PC by LPCAT - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PC is hydrolyzed to 1-acyl LPC by PLA2[6]
output	[SimpleEntity:R-ALL-1524028] 1-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SCE-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Saccharomyces cerevisiae [Reaction:R-SCE-1482547] 1-acyl LPC is acylated to PC by LPCAT - Saccharomyces cerevisiae [Reaction:R-SCE-1482533] 2-acyl LPC is acylated to PC by LPCAT - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-1482816
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-1482788] Acyl chain remodelling of PC
(precedingEvent)	[Reaction:R-SCE-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C [Reaction:R-SCE-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] [Reaction:R-SCE-1482547] 1-acyl LPC is acylated to PC by LPCAT
(inferredTo)	[Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6]