Reactome | DAG is hydrolyzed to 2-MAG by PNPLA2/3

DAG is hydrolyzed to 2-MAG by PNPLA2/3

Stable Identifier

R-HSA-1482811

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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At the endoplasmic reticulum (ER) membrane, patatin-like phospholipase domain-containing proteins 2/3 (PNPLA2/3) hydrolyze diacylglycerol (DAG), removing an acyl group to form 2-monoacylglycerol (2-MAG) (He et al. 2010, Jenkins et al. 2004, Basantani et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21068004	Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome Basantani, MK, Sitnick, MT, Cai, L, Brenner, DS, Gardner, NP, Li, JZ, Schoiswohl, G, Yang, K, Kumari, M, Gross, RW, Zechner, R, Kershaw, EE	J Lipid Res	2011
20034933	A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis He, S, McPhaul, C, Li, JZ, Garuti, R, Kinch, L, Grishin, NV, Cohen, JC, Hobbs, HH	J Biol Chem	2010
15364929	Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities Jenkins, CM, Mancuso, DJ, Yan, W, Sims, HF, Gibson, B, Gross, RW	J Biol Chem	2004