Reactome | 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL

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2-MAG is hydrolyzed to fatty acid and glycerol by MGLL Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1500582] acylglycerol lipase activity of MGLL dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
crossReference	[DatabaseIdentifier:11880214] Rhea:44688
dbId	1482543
displayName	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482883] Acyl chain remodeling of DAG and TAG - Homo sapiens
input	[SimpleEntity:R-ALL-1498728] 2-MAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482595] Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification [LiteratureReference:1482653] RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol [LiteratureReference:1482642] Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling [LiteratureReference:1482572] Structural basis for human monoglyceride lipase inhibition
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
orthologousEvent	[Reaction:R-PFA-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Plasmodium falciparum [Reaction:R-SCE-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Saccharomyces cerevisiae [Reaction:R-SPO-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Schizosaccharomyces pombe [Reaction:R-DDI-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Dictyostelium discoideum [Reaction:R-GGA-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Gallus gallus [Reaction:R-XTR-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Xenopus tropicalis [Reaction:R-DRE-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Danio rerio [Reaction:R-SSC-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Sus scrofa [Reaction:R-BTA-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Bos taurus [Reaction:R-CFA-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Canis familiaris [Reaction:R-RNO-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Rattus norvegicus [Reaction:R-MMU-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Mus musculus
output	[SimpleEntity:R-ALL-1500593] fatty acid [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-76116] Glycerol [cytosol]
precedingEvent	[Reaction:R-HSA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482543
summation	[Summation:1482575] At the endoplasmic reticulum (ER) membrane, monoglyceride li...

Referrals

(hasEvent)

[Pathway:R-HSA-1482883] Acyl chain remodeling of DAG and TAG

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