Reactome | DAG is hydrolyzed to 2-MAG by PNPLA2/3

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DAG is hydrolyzed to 2-MAG by PNPLA2/3 Show undefined attributes

catalystActivity	[CatalystActivity:10948625] lipoprotein lipase activity of PNPLA2/3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10948627
displayName	DAG is hydrolyzed to 2-MAG by PNPLA2/3
eventOf	[Pathway:R-CEL-1482883] Acyl chain remodeling of DAG and TAG - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-1482654] 2-MAG is transacylated to DAG by PNPLA2/3 - Caenorhabditis elegans [Reaction:R-CEL-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Homo sapiens
input	[SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DAG is hydrolyzed to 2-MAG by PNPLA2/3
output	[SimpleEntity:R-ALL-1498728] 2-MAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-CEL-1482654] 2-MAG is transacylated to DAG by PNPLA2/3 - Caenorhabditis elegans [Reaction:R-CEL-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1482811
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1482883] Acyl chain remodeling of DAG and TAG
(precedingEvent)	[Reaction:R-CEL-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 [Reaction:R-CEL-1482654] 2-MAG is transacylated to DAG by PNPLA2/3
(inferredTo)	[Reaction:R-HSA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3