Reactome | PE is hydrolyzed to 2-acyl LPE by PLA2[4]

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PE is hydrolyzed to 2-acyl LPE by PLA2[4] Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524134] glycerophospholipid phospholipase A1 activity of PLA2(4) [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482828
displayName	PE is hydrolyzed to 2-acyl LPE by PLA2[4]
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482839] Acyl chain remodelling of PE - Homo sapiens
followingEvent	[Reaction:R-HSA-1482545] 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C - Homo sapiens [Reaction:R-HSA-1482646] 2-acyl LPE is acylated to PE by LPEAT - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1500581] PE [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482664] Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PE is hydrolyzed to 2-acyl LPE by PLA2[4]
orthologousEvent	[Reaction:R-MMU-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Mus musculus [Reaction:R-SCE-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Saccharomyces cerevisiae [Reaction:R-SPO-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Schizosaccharomyces pombe [Reaction:R-DDI-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Dictyostelium discoideum [Reaction:R-GGA-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Gallus gallus [Reaction:R-XTR-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Xenopus tropicalis [Reaction:R-DRE-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Danio rerio [Reaction:R-SSC-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Sus scrofa [Reaction:R-BTA-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Bos taurus [Reaction:R-CFA-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Canis familiaris [Reaction:R-RNO-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Rattus norvegicus
output	[SimpleEntity:R-ALL-1498729] 2-acyl LPE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1483077] PE transports from the mitochondrial membrane to the ER - Homo sapiens [Reaction:R-HSA-1482646] 2-acyl LPE is acylated to PE by LPEAT - Homo sapiens [Reaction:R-HSA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Homo sapiens [Reaction:R-HSA-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482828
summation	[Summation:1482795] At the endoplasmic reticulum (ER) membrane, phosphatidyletha...

Referrals

(hasEvent)	[Pathway:R-HSA-1482839] Acyl chain remodelling of PE
(precedingEvent)	[Reaction:R-HSA-1482545] 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C [Reaction:R-HSA-1482646] 2-acyl LPE is acylated to PE by LPEAT

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