Reactome | PE is converted to PS by PTDSS2

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PE is converted to PS by PTDSS2 Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524132] transferase activity of PTDSS2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1483214] Williams, MG, 2011-08-12
dbId	1483089
displayName	PE is converted to PS by PTDSS2
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483101] Synthesis of PS - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1483170] PS transports from the ER membrane to the IM membrane - Homo sapiens [Reaction:R-HSA-1482776] PS is hydrolyzed to 1-acyl LPS by PLA2G2A - Homo sapiens [Reaction:R-HSA-1482771] PS is hydrolyzed to 1-acyl LPS by PLA2[9] - Homo sapiens [Reaction:R-HSA-1482897] PS is hydrolyzed to 2-acyl LPS by PLA2[10] - Homo sapiens
input	[SimpleEntity:R-ALL-200736] L-Ser [cytosol] [SimpleEntity:R-ALL-1500581] PE [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1483189] Purification and characterization of human phosphatidylserine synthases 1 and 2 [LiteratureReference:1483225] Genetic evidence that phosphatidylserine synthase II catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine in Chinese hamster ovary cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PE is converted to PS by PTDSS2
orthologousEvent	[Reaction:R-PFA-1483089] PE is converted to PS by PTDSS2 - Plasmodium falciparum [Reaction:R-DDI-1483089] PE is converted to PS by PTDSS2 - Dictyostelium discoideum [Reaction:R-GGA-1483089] PE is converted to PS by PTDSS2 - Gallus gallus [Reaction:R-XTR-1483089] PE is converted to PS by PTDSS2 - Xenopus tropicalis [Reaction:R-DRE-1483089] PE is converted to PS by PTDSS2 - Danio rerio [Reaction:R-SSC-1483089] PE is converted to PS by PTDSS2 - Sus scrofa [Reaction:R-BTA-1483089] PE is converted to PS by PTDSS2 - Bos taurus [Reaction:R-CFA-1483089] PE is converted to PS by PTDSS2 - Canis familiaris [Reaction:R-RNO-1483089] PE is converted to PS by PTDSS2 - Rattus norvegicus [Reaction:R-MMU-1483089] PE is converted to PS by PTDSS2 - Mus musculus
output	[SimpleEntity:R-ALL-1498751] ETA [cytosol] [SimpleEntity:R-ALL-1500646] PS [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1483077] PE transports from the mitochondrial membrane to the ER - Homo sapiens [Reaction:R-HSA-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Homo sapiens [Reaction:R-HSA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Homo sapiens [Reaction:R-HSA-1482646] 2-acyl LPE is acylated to PE by LPEAT - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1483089
summation	[Summation:1482966] At the endoplasmic reticulum (ER) membrane, phosphatidylseri...

Referrals

(hasEvent)	[Pathway:R-HSA-1483101] Synthesis of PS
(precedingEvent)	[BlackBoxEvent:R-HSA-1483170] PS transports from the ER membrane to the IM membrane [Reaction:R-HSA-1482776] PS is hydrolyzed to 1-acyl LPS by PLA2G2A [Reaction:R-HSA-1482771] PS is hydrolyzed to 1-acyl LPS by PLA2[9] [Reaction:R-HSA-1482897] PS is hydrolyzed to 2-acyl LPS by PLA2[10]

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