Reactome | GRB2 is indirectly recruited to p-KIT through SHP2

GRB2 is indirectly recruited to p-KIT through SHP2

Stable Identifier

R-HSA-1433428

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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GRB2 is indirectly recruited to p-KIT through SHP2

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GRB2 can be recruited indirectly to KIT through SHP2 (Tauchi et al. 1994). Y279, Y304, Y546 and Y584 (usually referred to as Y542 and Y580 in literature based on the SHP2 short isoform) are the potential sites of SHP2 tyrosyl phosphorylation and that Y546 is the major GRB2 binding site (Feng, et al. 1993, Araki, et al. 2003). This brings Grb2:SOS1 into proximity with the plasma membrane, where it can activate Ras.

Literature References

PubMed ID	Title	Journal	Year
11707405	ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen Glover, HR, Empereur, S, Nicholson, PR, Dilworth, SM	EMBO J	2001
10523831	Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction Pontén, E, Carlberg, M, Hermanson, M, Blume-Jensen, P, Lennartsson, J, Rönnstrand, L	Oncogene	1999
7523381	The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells Pawson, T, Shen, R, Mantel, C, Feng, GS, Broxmeyer, HE, Marshall, MS, Tauchi, T	J Biol Chem	1994