GRB2 is indirectly recruited to p-KIT through SHP2

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GRB2 can be recruited indirectly to KIT through SHP2 (Tauchi et al. 1994). Y279, Y304, Y546 and Y584 (usually referred to as Y542 and Y580 in literature based on the SHP2 short isoform) are the potential sites of SHP2 tyrosyl phosphorylation and that Y546 is the major GRB2 binding site (Feng, et al. 1993, Araki, et al. 2003). This brings Grb2:SOS1 into proximity with the plasma membrane, where it can activate Ras.
Literature References
PubMed ID Title Journal Year
11707405 ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen

Glover, HR, Empereur, S, Nicholson, PR, Dilworth, SM

EMBO J 2001
10523831 Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction

Pontén, E, Carlberg, M, Hermanson, M, Blume-Jensen, P, Lennartsson, J, Rönnstrand, L

Oncogene 1999
7523381 The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells

Pawson, T, Shen, R, Mantel, C, Feng, GS, Broxmeyer, HE, Marshall, MS, Tauchi, T

J Biol Chem 1994
Orthologous Events
Cite Us!