Reactome | TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]

Schema > Complex > Entries

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[BlackBoxEvent:R-HSA-9697747] Caspase-8 and FLIP(L) processing at TNFR signaling complex - Homo sapiens
created	[InstanceEdit:3465533] Shamovsky, V, 2013-05-17
dbId	3465532
displayName	TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
goCellularComponent	[GO_CellularComponent:161217] death-inducing signaling complex
hasComponent	[EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol] [EntityWithAccessionedSequence:R-HSA-3371356] CFLAR(1-480) [cytosol] [Complex:R-HSA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Mus musculus [Complex:R-RNO-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Rattus norvegicus [Complex:R-CFA-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Canis familiaris [Complex:R-BTA-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Bos taurus [Complex:R-SSC-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Sus scrofa [Complex:R-DRE-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Danio rerio [Complex:R-GGA-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Gallus gallus [Complex:R-DME-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Drosophila melanogaster
literatureReference	[LiteratureReference:3465412] N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway
maxDepth	4
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L)
producedByEvent	[Reaction:R-HSA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-3465532
updateTrackers	[UpdateTracker:9901454] Update Tracker - [Complex:3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - v74:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9901454] Update Tracker - [Complex:3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - v74:[updateContainedComponent]
(input)	[BlackBoxEvent:R-HSA-9697747] Caspase-8 and FLIP(L) processing at TNFR signaling complex
(output)	[Reaction:R-HSA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling

© 2026 Reactome

Cite Us!