Reactome | TRADD:TRAF2:RIPK1:FADD [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Canis familiaris [Complex:R-CFA-3465431] DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] - Canis familiaris
consumedByEvent	[BlackBoxEvent:R-CFA-5357828] RIPK1 is cleaved by CASP8 - Canis familiaris [Reaction:R-CFA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10235756
displayName	TRADD:TRAF2:RIPK1:FADD [cytosol]
hasComponent	2 × [GenomeEncodedEntity:R-CFA-54639] Ghost homologue of FADD [cytosol] [Complex:R-CFA-140935] TRAF2:TRADD:RIPK1 [cytosol]
inDisease	false
inferredFrom	[DefinedSet:R-HSA-2671814] DISC [plasma membrane] - Homo sapiens [Complex:R-HSA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Homo sapiens
maxDepth	3
name	TRADD:TRAF2:RIPK1:FADD
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-140977
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-CFA-3465431] DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] [Complex:R-CFA-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] [Complex:R-CFA-2671812] TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] [Complex:R-CFA-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol]
(input)	[Reaction:R-CFA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling [BlackBoxEvent:R-CFA-5357828] RIPK1 is cleaved by CASP8
(inferredTo)	[DefinedSet:R-HSA-2671814] DISC [plasma membrane] [Complex:R-HSA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol]