Reactome | Translocation of BIM to mitochondria

Schema > Reaction > Entries

Translocation of BIM to mitochondria Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10455870
displayName	Translocation of BIM to mitochondria
eventOf	[Pathway:R-SSC-111446] Activation of BIM and translocation to mitochondria - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Sus scrofa [Reaction:R-SSC-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:161847] protein insertion into mitochondrial membrane
inferredFrom	[Reaction:R-HSA-139919] Translocation of BIM to mitochondria - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-140525] phospho-BCL2L11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Translocation of BIM to mitochondria
output	[EntityWithAccessionedSequence:R-SSC-3145027] phospho-BCL2L11 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-SSC-139918] Phosphorylation of BIM by JNK - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-139919
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-SSC-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL [Reaction:R-SSC-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
(hasEvent)	[Pathway:R-SSC-111446] Activation of BIM and translocation to mitochondria
(inferredTo)	[Reaction:R-HSA-139919] Translocation of BIM to mitochondria