Reactome | Phosphorylation of BIM by JNK

Schema > Reaction > Entries

Phosphorylation of BIM by JNK Show undefined attributes

catalystActivity	[CatalystActivity:140204] protein serine/threonine kinase activity of MAPK8 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
dbId	139918
displayName	Phosphorylation of BIM by JNK
eventOf	[Pathway:R-HSA-111446] Activation of BIM and translocation to mitochondria - Homo sapiens
followingEvent	[Reaction:R-HSA-139919] Translocation of BIM to mitochondria - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-140524] BIM sequestered to dynein (DLC1) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140440] JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation of BIM by JNK MAPK8 phosphorylates BCL2L11
orthologousEvent	[Reaction:R-GGA-139918] Phosphorylation of BIM by JNK - Gallus gallus [Reaction:R-SSC-139918] Phosphorylation of BIM by JNK - Sus scrofa [Reaction:R-BTA-139918] Phosphorylation of BIM by JNK - Bos taurus [Reaction:R-CFA-139918] Phosphorylation of BIM by JNK - Canis familiaris [Reaction:R-RNO-139918] Phosphorylation of BIM by JNK - Rattus norvegicus [Reaction:R-MMU-139918] Phosphorylation of BIM by JNK - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-140526] Dynein (DLC1) on microtubules [plasma membrane] [EntityWithAccessionedSequence:R-HSA-140525] p-BCL2L11 [cytosol]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:3145024] Orlic-Milacic, M, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-139918
summation	[Summation:179063] MAPK8 (JNK) phosphorylates BCL2L11 (BIM) on a DLC-binding mo...
updateTrackers	[UpdateTracker:9787891] Update Tracker - [Reaction:139918] Phosphorylation of BIM by JNK - v44:[add_removeOutput, modifyText] [UpdateTracker:9779109] Update Tracker - [Reaction:139918] Phosphorylation of BIM by JNK - v66:[addInput, addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9787891] Update Tracker - [Reaction:139918] Phosphorylation of BIM by JNK - v44:[add_removeOutput, modifyText] [UpdateTracker:9779109] Update Tracker - [Reaction:139918] Phosphorylation of BIM by JNK - v66:[addInput, addOutput]
(precedingEvent)	[Reaction:R-HSA-139919] Translocation of BIM to mitochondria
(hasEvent)	[Pathway:R-HSA-111446] Activation of BIM and translocation to mitochondria