Translocation of BIM to mitochondria

Stable Identifier
R-HSA-139919
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
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Translocation of BIM to mitochondria
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Once BCL2L11 (BIM) dissociates from the cytoskeleton, it translocates to the outer mitochondrial membrane where it associates with BCL2 (Puthalakath et al. 1999).

Literature References
PubMed ID Title Journal Year
10198631 The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

Puthalakath, H, Huang, DC, O'Reilly, LA, King, SM, Strasser, A

Mol Cell 1999
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Output
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Event Information
Go Biological Process
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (0001844)
Orthologous Events
Translocation of BIM to mitochondria (Bos taurus)
Translocation of BIM to mitochondria (Canis familiaris)
Translocation of BIM to mitochondria (Danio rerio)
Translocation of BIM to mitochondria (Mus musculus)
Translocation of BIM to mitochondria (Rattus norvegicus)
Translocation of BIM to mitochondria (Sus scrofa)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)