Reactome | Activation of BAD and translocation to mitochondria

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Activation of BAD and translocation to mitochondria Show undefined attributes

authored	[InstanceEdit:140538] Gopinathrao, G, 2004-08-19 20:25:42
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
crossReference	[DatabaseIdentifier:12819581] BioModels Database:BIOMD0000000943 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940
dbId	111447
displayName	Activation of BAD and translocation to mitochondria
eventOf	[Pathway:R-HSA-114452] Activation of BH3-only proteins - Homo sapiens
figure	[Figure:140539] /figures/bad1.jpg
goBiologicalProcess	[GO_BiologicalProcess:5673453] positive regulation of protein localization to mitochondrion
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-198347] AKT phosphorylates BAD - Homo sapiens [Reaction:R-HSA-139899] Sequestration of BAD protein by 14-3-3 - Homo sapiens [Reaction:R-HSA-139906] Activation of BAD by calcineurin - Homo sapiens [Reaction:R-HSA-139905] Translocation of activated BAD protein to mitochondria - Homo sapiens [Reaction:R-HSA-139897] BAD displaces tBID from BCL-2 sequestration - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2013-03-31
literatureReference	[LiteratureReference:114463] BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function.
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Activation of BAD and translocation to mitochondria
orthologousEvent	[Pathway:R-XTR-111447] Activation of BAD and translocation to mitochondria - Xenopus tropicalis [Pathway:R-DRE-111447] Activation of BAD and translocation to mitochondria - Danio rerio [Pathway:R-SSC-111447] Activation of BAD and translocation to mitochondria - Sus scrofa [Pathway:R-BTA-111447] Activation of BAD and translocation to mitochondria - Bos taurus [Pathway:R-CFA-111447] Activation of BAD and translocation to mitochondria - Canis familiaris [Pathway:R-RNO-111447] Activation of BAD and translocation to mitochondria - Rattus norvegicus [Pathway:R-MMU-111447] Activation of BAD and translocation to mitochondria - Mus musculus
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165094] Vaux, D, 0000-00-00 00:00:00
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-111447
summation	[Summation:140545] The switching on/off of its phosphorylation by growth/surviv...
updateTrackers	[UpdateTracker:9787543] Update Tracker - [Pathway:111447] Activation of BAD and translocation to mitochondria - v44:[add_removeHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9787543] Update Tracker - [Pathway:111447] Activation of BAD and translocation to mitochondria - v44:[add_removeHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-114452] Activation of BH3-only proteins