Reactome | Translocation of activated BAD protein to mitochondria

Schema > Reaction > Entries

Translocation of activated BAD protein to mitochondria Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9993342
displayName	Translocation of activated BAD protein to mitochondria
eventOf	[Pathway:R-MMU-111447] Activation of BAD and translocation to mitochondria - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-139897] BAD displaces tBID from BCL-2 sequestration - Mus musculus [Reaction:R-MMU-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Mus musculus [Reaction:R-MMU-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:161847] protein insertion into mitochondrial membrane
inferredFrom	[Reaction:R-HSA-139905] Translocation of activated BAD protein to mitochondria - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-50662] Bad [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Translocation of activated BAD protein to mitochondria
output	[EntityWithAccessionedSequence:R-MMU-114242] Bad [mitochondrial outer membrane]
precedingEvent	[Reaction:R-MMU-139906] Activation of BAD by calcineurin - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-139905
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL [Reaction:R-MMU-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 [Reaction:R-MMU-139897] BAD displaces tBID from BCL-2 sequestration
(hasEvent)	[Pathway:R-MMU-111447] Activation of BAD and translocation to mitochondria
(inferredTo)	[Reaction:R-HSA-139905] Translocation of activated BAD protein to mitochondria