Reactome | PRLR binds SCF beta-TrCP complex

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PRLR binds SCF beta-TrCP complex Show undefined attributes

authored	[InstanceEdit:1363240] Jupe, S, 2011-06-13
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1370501] Jupe, S, 2011-07-04
dbId	1370500
displayName	PRLR binds SCF beta-TrCP complex
edited	[InstanceEdit:1671724] Jupe, S, 2011-10-17
eventOf	[Pathway:R-HSA-1170546] Prolactin receptor signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1170539] Prolactin receptor is internalized - Homo sapiens
input	[Complex:R-HSA-206748] BTRC:CUL1:RBX1:SKP1 [cytosol] [Complex:R-HSA-1977946] PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1302716] Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PRLR binds SCF beta-TrCP complex
orthologousEvent	[Reaction:R-GGA-1370500] PRLR binds SCF beta-TrCP complex - Gallus gallus [Reaction:R-XTR-1370500] PRLR binds SCF beta-TrCP complex - Xenopus tropicalis [Reaction:R-DRE-1370500] PRLR binds SCF beta-TrCP complex - Danio rerio [Reaction:R-BTA-1370500] PRLR binds SCF beta-TrCP complex - Bos taurus [Reaction:R-CFA-1370500] PRLR binds SCF beta-TrCP complex - Canis familiaris [Reaction:R-RNO-1370500] PRLR binds SCF beta-TrCP complex - Rattus norvegicus [Reaction:R-MMU-1370500] PRLR binds SCF beta-TrCP complex - Mus musculus
output	[Complex:R-HSA-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1370505] PRLR is phosphorylated at Ser-349 - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1977929] Goffin, V, 2011-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1370500
summation	[Summation:1370507] Phosphorylation of PRLR on Ser-349 by an unidentified kinase...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-1170539] Prolactin receptor is internalized
(hasEvent)	[Pathway:R-HSA-1170546] Prolactin receptor signaling

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