PRLR binds SCF beta-TrCP complex

Stable Identifier
R-HSA-1370500
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylation of PRLR on Ser-349 by an unidentified kinase enables recruitment of the SCF beta-TrCP ubiquitin ligase complex, which catalyzes ubiquitination of the receptor (Li et al. 2004). This downregulation mechanism is impaired in some forms of breast cancer (Li et al. 2006).

Literature References
PubMed ID Title Journal Year
15082796 Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

Li, Y, Kumar, KG, Tang, W, Spiegelman, VS, Fuchs, SY

Mol Cell Biol 2004
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