PRLR binds SCF beta-TrCP complex

Stable Identifier
R-HSA-1370500
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PRLR binds SCF beta-TrCP complex
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Phosphorylation of PRLR on Ser-349 by an unidentified kinase enables recruitment of the SCF beta-TrCP ubiquitin ligase complex, which catalyzes ubiquitination of the receptor (Li et al. 2004). This downregulation mechanism is impaired in some forms of breast cancer (Li et al. 2006).
Literature References
PubMed ID Title Journal Year
15082796 Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

Fuchs, SY, Spiegelman, VS, Tang, W, Li, Y, Kumar, KG

Mol Cell Biol 2004
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Orthologous Events
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Authored
Jupe, S  (2011-06-13)
Reviewed
Goffin, V  (2011-11-08)
Created
Jupe, S  (2011-07-04)
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