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Schema
>
BlackBoxEvent
>
Entries
Prolactin receptor is internalized
Show undefined attributes
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authored
[InstanceEdit:1363240] Jupe, S, 2011-06-13
category
omitted
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:171907] endosome lumen
[Compartment:984] extracellular region
created
[InstanceEdit:1170541] Jupe, S, 2011-01-19
dbId
1170539
displayName
Prolactin receptor is internalized
edited
[InstanceEdit:1671724] Jupe, S, 2011-10-17
eventOf
[Pathway:R-HSA-1170546] Prolactin receptor signaling - Homo sapiens
input
[Complex:R-HSA-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1302716] Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
Prolactin receptor is internalized
orthologousEvent
[BlackBoxEvent:R-GGA-1170539] Prolactin receptor is internalized - Gallus gallus
[BlackBoxEvent:R-XTR-1170539] Prolactin receptor is internalized - Xenopus tropicalis
[BlackBoxEvent:R-DRE-1170539] Prolactin receptor is internalized - Danio rerio
[BlackBoxEvent:R-BTA-1170539] Prolactin receptor is internalized - Bos taurus
[BlackBoxEvent:R-CFA-1170539] Prolactin receptor is internalized - Canis familiaris
[BlackBoxEvent:R-RNO-1170539] Prolactin receptor is internalized - Rattus norvegicus
[BlackBoxEvent:R-MMU-1170539] Prolactin receptor is internalized - Mus musculus
output
[Complex:R-HSA-206748] BTRC:CUL1:RBX1:SKP1 [cytosol]
[Complex:R-HSA-1370498] PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen]
precedingEvent
[Reaction:R-HSA-1370500] PRLR binds SCF beta-TrCP complex - Homo sapiens
releaseDate
2011-12-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1977929] Goffin, V, 2011-11-08
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-1170539
summation
[Summation:1302696] PRLR is regulated by ubiquitination of the activated recepto...
Referrals
(hasEvent)
[Pathway:R-HSA-1170546] Prolactin receptor signaling
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