Reactome | Phosphorylation of PRLR on Ser-349 by an unidentified kinase...

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created	[InstanceEdit:1370502] Jupe, S, 2011-07-04
dbId	1370507
displayName	Phosphorylation of PRLR on Ser-349 by an unidentified kinase...
literatureReference	[LiteratureReference:1302716] Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase [LiteratureReference:1302673] Stabilization of prolactin receptor in breast cancer cells
modified	[InstanceEdit:1370509] Jupe, S, 2011-07-04
schemaClass	Summation
text	Phosphorylation of PRLR on Ser-349 by an unidentified kinase enables recruitment of the SCF beta-TrCP ubiquitin ligase complex, which catalyzes ubiquitination of the receptor (Li et al. 2004). This downregulation mechanism is impaired in some forms of breast cancer (Li et al. 2006).

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