Reactome | PRLR is phosphorylated at Ser-349

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PRLR is phosphorylated at Ser-349 Show undefined attributes

authored	[InstanceEdit:1363240] Jupe, S, 2011-06-13
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1370502] Jupe, S, 2011-07-04
dbId	1370505
displayName	PRLR is phosphorylated at Ser-349
edited	[InstanceEdit:1671724] Jupe, S, 2011-10-17
eventOf	[Pathway:R-HSA-1170546] Prolactin receptor signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-1370500] PRLR binds SCF beta-TrCP complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-976956] PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1302716] Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PRLR is phosphorylated at Ser-349
orthologousEvent	[BlackBoxEvent:R-GGA-1370505] PRLR is phosphorylated at Ser-349 - Gallus gallus [BlackBoxEvent:R-XTR-1370505] PRLR is phosphorylated at Ser-349 - Xenopus tropicalis [BlackBoxEvent:R-DRE-1370505] PRLR is phosphorylated at Ser-349 - Danio rerio [BlackBoxEvent:R-SSC-1370505] PRLR is phosphorylated at Ser-349 - Sus scrofa [BlackBoxEvent:R-BTA-1370505] PRLR is phosphorylated at Ser-349 - Bos taurus [BlackBoxEvent:R-CFA-1370505] PRLR is phosphorylated at Ser-349 - Canis familiaris [BlackBoxEvent:R-RNO-1370505] PRLR is phosphorylated at Ser-349 - Rattus norvegicus [BlackBoxEvent:R-MMU-1370505] PRLR is phosphorylated at Ser-349 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1977946] PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1671687] PRLR activation - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1977929] Goffin, V, 2011-11-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1370505
summation	[Summation:1370504] The PRL responsiveness of target cells is negatively regulat...

Referrals

(hasEvent)	[Pathway:R-HSA-1170546] Prolactin receptor signaling
(precedingEvent)	[Reaction:R-HSA-1370500] PRLR binds SCF beta-TrCP complex

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