Reactome | PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]

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PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-HSA-1170539] Prolactin receptor is internalized - Homo sapiens
created	[InstanceEdit:1369100] Jupe, S, 2011-07-04
dbId	1369085
displayName	PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]
hasComponent	[Complex:R-HSA-206748] BTRC:CUL1:RBX1:SKP1 [cytosol] [Complex:R-HSA-1977946] PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - Mus musculus [Complex:R-RNO-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - Rattus norvegicus [Complex:R-CFA-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - Canis familiaris [Complex:R-BTA-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - Bos taurus [Complex:R-DRE-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - Danio rerio [Complex:R-XTR-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - Gallus gallus
isChimeric	false
maxDepth	5
modified	[InstanceEdit:8942939] Jupe, Steve, 2016-10-21
name	PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex
negativelyRegulates	[NegativeRegulation:R-HSA-1370510] Negative regulation by 'PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]'
producedByEvent	[Reaction:R-HSA-1370500] PRLR binds SCF beta-TrCP complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1369085
updateTrackers	[UpdateTracker:9872204] Update Tracker - [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [UpdateTracker:9903597] Update Tracker - [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - v80:[updateContainedComponent] [UpdateTracker:9897489] Update Tracker - [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - v62:[updateContainedComponent] [UpdateTracker:9895133] Update Tracker - [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - v59:[modifyName, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9872204] Update Tracker - [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [UpdateTracker:9903597] Update Tracker - [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - v80:[updateContainedComponent] [UpdateTracker:9897489] Update Tracker - [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - v62:[updateContainedComponent] [UpdateTracker:9895133] Update Tracker - [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] - v59:[modifyName, updateContainedComponent]
(input)	[BlackBoxEvent:R-HSA-1170539] Prolactin receptor is internalized
(output)	[Reaction:R-HSA-1370500] PRLR binds SCF beta-TrCP complex
(regulator)	[NegativeRegulation:R-HSA-1370510] Negative regulation by 'PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]'

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