Expression of NPAS2

Stable Identifier
R-HSA-1368065
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Synonyms
NPAS2 gene produces NPAS2
ReviewStatus
5/5
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Expression of NPAS2
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The NPAS2 gene is transcribed to yield mRNA and the mRNA is transcribed to yield NPAS2 protein (Zhou et al. 1997, Matsumura et al. 2013, also inferred from mouse homologs). Transcription of NPAS2 is enhanced by the RORA:Coactivator complex and repressed by the REV-ERBA:Corepressor complex. As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). As inferred from mouse, ROR-alpha binds the promoter of the NPAS2 gene and enhances transcription.
Literature References
PubMed ID Title Journal Year
9012850 Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system

Ring, HZ, Barnard, M, Russell, DW, Li, X, Richardson, J, Francke, U, Shelton, J, Tian, H, McKnight, SL, Zhou, YD

Proc Natl Acad Sci U S A 1997
24196956 Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2)

Node, K, Akashi, M, Matsubara, C, Takumi, T, Matsumura, R

J. Biol. Chem. 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NR1D1:heme:Corepressors:NPAS2 gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Regulator
RORA:EP300:NPAS2 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Npas2 (Mus musculus)
Authored
May, B  (2011-06-22)
Reviewed
Somers, J  (2021-01-23)
Delaunay, F  (2012-01-28)
Kersten, S  (2009-06-08)
Created
May, B  (2011-06-30)
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