Reactome | Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoform...

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created	[InstanceEdit:1251989] Orlic-Milacic, Marija, 2011-04-26
dbId	1251993
displayName	Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoform...
literatureReference	[LiteratureReference:1251998] Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment [LiteratureReference:1252006] Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4
modified	[InstanceEdit:9607288] Orlic-Milacic, Marija, 2018-05-01
schemaClass	Summation
text	Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoforms are cleaved by ADAM17 metalloproteinase to yield ligand-bound ERBB4 extracellular domain and membrane bound ERBB4 fragment of 80 kDa (ERBB4m80) (Rio et al. 2000, Cheng et al. 2003).

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