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Cleavage of P-ERBB4jmA isoforms by ADAM17
Stable Identifier
R-HSA-1251992
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
Nuclear signaling by ERBB4 (Homo sapiens)
Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)
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Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoforms are cleaved by ADAM17 metalloproteinase to yield ligand-bound ERBB4 extracellular domain and membrane bound ERBB4 fragment of 80 kDa (ERBB4m80) (Rio et al. 2000, Cheng et al. 2003).
Participants
Input
p-ERBB4 JM-A homodimers [plasma membrane]
(Homo sapiens)
Output
ERBB4_ECD [extracellular region]
(Homo sapiens)
ERBB4m80 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Nuclear signaling by ERBB4 (Homo sapiens)
Catalyst Activity
metalloendopeptidase activity of ADAM17 [plasma membrane]
Physical Entity
ADAM17 [plasma membrane]
(Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Cleavage of P-ERBB4jmA isoforms by Adam17 (Homo sapiens)
Authored
Orlic-Milacic, M (2011-11-04)
Stern, DF (2019-02-21)
Reviewed
Zeng, F (2011-11-11)
Harris, RC (2011-11-11)
Earp HS, 3rd (2012-02-20)
Misior, AM (2012-02-20)
Created
Orlic-Milacic, M (2011-04-26)
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