Cleavage of P-ERBB4jmA isoforms by ADAM17

Stable Identifier
R-HSA-1251992
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Cleavage of P-ERBB4jmA isoforms by ADAM17
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Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoforms are cleaved by ADAM17 metalloproteinase to yield ligand-bound ERBB4 extracellular domain and membrane bound ERBB4 fragment of 80 kDa (ERBB4m80) (Rio et al. 2000, Cheng et al. 2003).

Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of ADAM17 [plasma membrane]

Physical Entity
ADAM17 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Cleavage of P-ERBB4jmA isoforms by Adam17 (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Zeng, F  (2011-11-11)
Harris, RC  (2011-11-11)
Earp HS, 3rd  (2012-02-20)
Misior, AM  (2012-02-20)
Created
Orlic-Milacic, M  (2011-04-26)
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