Cleavage of P-ERBB4jmA isoforms by ADAM17

Stable Identifier
R-HSA-1251992
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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General
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Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoforms are cleaved by ADAM17 metalloproteinase to yield ligand-bound ERBB4 extracellular domain and membrane bound ERBB4 fragment of 80 kDa (ERBB4m80) (Rio et al. 2000, Cheng et al. 2003).
Participants
Participates
Catalyst Activity

metalloendopeptidase activity of ADAM17 [plasma membrane]

Inferred From
Authored
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