Reactome | Trans-autophosphorylation of p-Y877-ERBB2 heterodimers

Schema > Reaction > Entries

Trans-autophosphorylation of p-Y877-ERBB2 heterodimers Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1963577] protein tyrosine kinase activity of p-Y877-ERBB2 heterodimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
dbId	1963581
displayName	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
edited	[InstanceEdit:1816717] D'Eustachio, P, 2011-10-25
eventOf	[Pathway:R-HSA-1227986] Signaling by ERBB2 - Homo sapiens
followingEvent	[Reaction:R-HSA-1963578] SHC1 binds phosphorylated ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-6785636] Phosphorylated ERBB2 heterodimers bind MEMO1 - Homo sapiens [Reaction:R-HSA-1306953] GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 - Homo sapiens [Reaction:R-HSA-8864105] PTPN18 binds ERBB2:EGFR heterodimers - Homo sapiens [Reaction:R-HSA-1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2 - Homo sapiens [Reaction:R-HSA-1358798] RNF41 binds neuregulin-activated ERBB3 - Homo sapiens [Reaction:R-HSA-1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - Homo sapiens [Reaction:R-HSA-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - Homo sapiens [Reaction:R-HSA-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers - Homo sapiens [Reaction:R-HSA-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-8863804] PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 - Homo sapiens [Reaction:R-HSA-1251944] PLCG1 binds to p-ERBB2:p-EGFR - Homo sapiens [Reaction:R-HSA-8847995] Activated ERBB2 binds PTK6 (BRK) - Homo sapiens [Reaction:R-HSA-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR - Homo sapiens
input	43 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-1963584] p-Y877-ERBB2 heterodimers [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1810436] Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
orthologousEvent	[Reaction:R-CEL-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Caenorhabditis elegans [Reaction:R-DME-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Drosophila melanogaster [Reaction:R-GGA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Gallus gallus [Reaction:R-DRE-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Danio rerio [Reaction:R-SSC-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Sus scrofa [Reaction:R-BTA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Bos taurus [Reaction:R-CFA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Canis familiaris [Reaction:R-RNO-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Rattus norvegicus [Reaction:R-MMU-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Mus musculus
output	43 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-1963580] Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane]
precedingEvent	[Reaction:R-HSA-1963586] SRC family kinases phosphorylate ERBB2 - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1963581
summation	[Summation:1963570] Phosphorylation of ERBB2 on tyrosine residue Y877 by SRC fam...

Referrals

(precedingEvent)

(hasEvent)

[Pathway:R-HSA-1227986] Signaling by ERBB2

Cite Us!