GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer

Stable Identifier
R-HSA-1250488
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated ERBB2:EGFR heterodimer recruits GRB2:SOS1 complex through phosphorylated tyrosine residues on either ERBB2 or EGFR that serve as direct docking sites for GRB2 (Xie et al. 1995).

Literature References
Participants
Participant Of
Inferred From
Authored
Reviewed
Created